University of California San Francisco

Tippi MacKenzie, MD

Tippi MacKenzie large headshot
Tippi
MacKenzie
MD

Professor of Surgery
Benioff UCSF Professor of Children’s Health 
Director, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF 
Co-Director, Center for Maternal-Fetal Precision Medicine 
John G. Bowes Distinguished Professor of Stem Cell and Tissue Biology

Address

35 Medical Center Way, #902D
San Francisco, CA 94143
United States

Email: [email protected]

Biography

Tippi MacKenzie is a pediatric and fetal surgeon who is focused on developing better ways to diagnose and treat genetic diseases before birth. She leads a translational research lab examining the unique biology between the mother and her fetus, with the idea that pregnancy complications such as preterm labor arise from a breakdown in maternal-fetal tolerance. At present, the MacKenzie group is focused on preterm labor and fetal therapies including stem cell transplantation, enzyme replacement therapy, and gene therapy.

Videos

Education

Institution Degree Dept or School End Date
Children's Hospital of Philadelphia Fellow Pediatric Surgery 2007
Brigham and Women's Hospital Chief Resident Surgery 2005
Brigham and Women's Hospital Residency Surgery 2004
Children's Hospital of Philadelphia Postdoctoral Studies Fetal Therapy 2002
Stanford University M.D. Medicine 1997

Board Certifications

  • American Board of Surgery, 2006

Clinical Expertise

Advanced Laparoscopy
Birth Defects
Endocrine and Biliary Surgery
Fetal Surgery
Pediatric Surgery

Program Affiliations

  • Fetal Treatment Center
  • Biomedical Sciences Program
  • Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
  • Center for Maternal-Fetal Precision Medicine

Grants and Funding

  • Prenatal AAV9 gene replacement therapy for patients with severe infantile GM1 gangliosidosis | NIH | 2026-04-01 - 2029-03-31 | Role: Principal Investigator
  • Phase 1 Study of In Utero Enzyme Replacement Therapy for the Treatment of Lysosomal Storage Diseases | NIH/NICHHD | 2022-09-20 - 2027-04-30 | Role: Principal Investigator
  • Phase 1 Study of In Utero Enzyme Replacement Therapy for the Treatment of Lysosomal Storage Diseases | NIH | 2022-09-20 - 2027-04-30 | Role: Principal Investigator
  • Developing gene therapy strategies to treat alpha thalassemia | NIH | 2022-01-01 - 2025-12-31 | Role: Principal Investigator
  • Developing gene therapy strategies to treat alpha thalassemia | NIH/NHLBI | 2022-01-01 - 2025-12-31 | Role: Principal Investigator
  • Autoimmune Regulator gene (Aire)-mediated tolerance to pregnancy-associated self-antigens | NIH | 2019-08-21 - 2025-07-31 | Role: Principal Investigator
  • In utero hematopoietic stem cell transplantation for the treatment of fetuses with alpha thalassemia major (phase I clinical trial) | California Institute for Regenerative Medicine (CIRM) | 2017-08-01 - 2022-07-31 | Role: Principal Investigator
  • A precision medicine approach to detect dysbiosis and immune activation in preterm labor | Burroughs Wellcome Fund Preterm Labor Initiative | 2017-07-01 - 2021-06-30 | Role: Principal Investigator
  • T cell activation and the breakdown of maternal-fetal tolerance in preterm labor | NIH | 2015-06-15 - 2021-05-31 | Role: Principal Investigator

Research Narrative

Dr. MacKenzie has an active laboratory and is a member of the Biomedical Sciences Program and the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research. Her research focus is on mechanisms of tolerance induction following in utero stem cell transplantation  and the pathophysiology of prenatally diagnosed diseases, such as congenital diaphragmatic hernia and gastroschisis, to identify biomarkers that predict prognosis and molecular pathways that may be targets for prenatal intervention.

Research Interests

In-Utero Stem Cell Transplantation

Research Pathways

Basic Biomedical & Translational Research
Clinical Discovery & Health Services Research

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 10
  1. In Utero Hematopoietic Cell Transplantation in Fetuses with Alpha Thalassemia Major: A Phase 1 Clinical Trial.
    MacKenzie TC, Lianoglou BR, Gonzalez J, Dvorak CC, Kharbanda S, Herzeg A, Canepa E, Kreger EM, Frascoli M, Sper R, Gupta A, Leung J, Tang Q, Sinha R, Worthington AK, Gano D, Coco Bakkour S, Chafets D, Keller RL, Shimotake J, Lal A, Glenn OA, Moon-Grady A, Vichinsky EP| | PubMed
  2. Combinatorial base editing couples disease correction with lineage amplification in hematopoietic stem and progenitor cells.
    Jia K, Soupene E, Sinha R, Lesch BJ, Pendergast MA, Choi R, Zhang X, Foppiani EM, Kostamo Z, Chu SN, Sharma D, Yu X, Cordero M, Walters MC, MacKenzie TC, Sheehan VA, Cromer MK| | PubMed
  3. Single-cell spatiotemporal dissection of the human maternal-fetal interface.
    Wang C, Zhou Y, Wang Y, Guha TK, Luo Z, Mustafaraj A, McIntyre TI, Schwab ME, Davidson BR, Reeder GC, Wong RJ, England SK, Gonzalez JM, Blelloch R, Combes AJ, Giudice LC, Erlebacher A, MacKenzie TC, Stevenson DK, Shaw GM, Snyder MP, Sun X, Winn VD, Fisher SJ, Li J| | PubMed
  4. Attitudes Toward Prenatal Interventions in the Fanconi Anemia Community.
    Lum T, Lee C, MacKenzie T, Lianoglou B, Czechowicz A| | PubMed
  5. Single nuclei and spatial profiling of sacrococcygeal teratomas reveals cellular composition and X inactivation heterogeneity.
    Rojas EJ, Giannikou K, Huang BJ, Cho SJ, Cordero MA, Pena D, Vu L, Bagrodia A, Derderian SC, MacKenzie TC, Laird DJ| | PubMed
  6. Evidence for Maternal Autoantibodies in the Pathogenesis of Preterm Birth.
    Rackaityte E, Borges B, Kortbawi HM, Miller HS, Shao SJ, Zorn KC, Caspar C, Wong R, McCarthy F, Creery JS, Mayer M, Kouame E, Puccinelli RR, Kistler AL, Yu DJL, Ganem SR, DeRisi A, Kawaja Q, Wang CY, Saxena A, Oltman S, Kung AF, Mann SA, Mitchell A, Huang D, Rizzuto G, Baer RJ, Mandel-Brehm C, Ryckman KK, Gaw SL, Hillman SL, Jelliffe-Pawlowski LL, Halkias J, Sobhani NC, Anderson MS, Trespidi F, Alpin C, Bosoni T, Albertini R, Bellingeri C, Gardella B, Borghesi A, Prince N, Lasky-Su J, Wilson MR, Cedars M, Elias JE, MacKenzie TC, DeRisi JL| | PubMed
  7. Lentiviral vectors for hematopoietic stem cell gene therapy restore α-globin expression in α-thalassemia red blood cells.
    Segura EER, Hart K, Campo Fernandez B, Brown D, Tam K, Gutierrez Garcia A, Seigneurbieux E, Li K, Mulumba C, Blakely E, Masiuk K, Sinha R, Sharma D, Everett J, Hogenauer M, Cromer MK, Bushman F, MacKenzie TC, Kohn DB| | PubMed
  8. GFP-on mouse model for interrogation of in vivo gene editing.
    Dib C, Queenan JA, Swartzrock L, Willner H, Denis M, Ahmed N, Moulana Zada F, Borges B, Charlesworth CT, Lum T, Yates BP, Kwon CY, Scorzo AV, Davis SC, Davis JR, He R, Xie J, Gao G, MacKenzie TC, Liu DR, Newby GA, Czechowicz AD| | PubMed
  9. Integrated single-nuclei and spatial transcriptomic profiling of human sacrococcygeal teratomas reveals heterogeneity in cellular composition and X-chromosome inactivation.
    Rojas EJ, Giannikou K, Huang BJ, Cho SJ, Cordero MA, Pena D, Vu L, Bagrodia A, Derderian SC, MacKenzie TC, Laird DJ| | PubMed
  10. In utero genetic therapy: Treatment of early onset neurological disorders before they start.
    Borges B, Brown SM, MacKenzie TC, Sumner CJ| | PubMed