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Pediatric Surgery »  Faculty »  Pediatric Surgeons »  Tippi MacKenzie, M.D.

Tippi MacKenzie, M.D.

Professor of Surgery
Division of Pediatric Surgery
Co-director, UCSF Center for Maternal-Fetal Precision Medicine



Contact Information

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  • 1987-91, Harvard University, B.A., Biochemistry
  • 1992-97, Stanford University School of Medicine, M.D., Medicine
  • 1998-99, Brigham and Women's Hospital, Resident, Surgery
  • 2002-04, Brigham and Women's Hospital, Resident, Surgery
  • 2004-05, Brigham and Women's Hospital, Chief Resident, Surgery
  • 1999-02, Children's Hospital of Philadelphia, Fellow, Fetal Therapy
  • 2005-07, Children's Hospital of Philadelphia, Fellow, Pediatric Surgery
  • American Board of Surgery, 2006
  • Fetal Treatment Center
  • Biomedical Sciences Program
  • Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
  • Center for Maternal-Fetal Precision Medicine
  • Advanced Laparoscopy
  • Birth Defects
  • Endocrine and Biliary Surgery
  • Fetal Surgery
  • Pediatric Surgery
  • In-Utero Stem Cell Transplantation

Dr. Tippi MacKenzie is Professor of Surgery at the UCSF Division of Pediatric Surgery and the Fetal Treatment Center. Dr. MacKenzie obtained her undergraduate degree in Biochemistry at Harvard, then came to the Bay Area for medical school at Stanford. She did her surgical residency at Brigham and Women's Hospital in Boston. During this time, she took three years to do research on fetal surgery and in utero stem cell transplantation at the Children's Hospital of Philadelphia. Following residency, she returned to CHOP for her clinical pediatric surgery fellowship.

Dr. MacKenzie's clinical interests include fetal surgery, advanced laparoscopy, and endocrine and biliary surgery.

Dr. MacKenzie has an active laboratory and is a member of the Biomedical Sciences Program and the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research. Her research focus is on mechanisms of tolerance induction following in utero stem cell transplantation  and the pathophysiology of prenatally diagnosed diseases, such as congenital diaphragmatic hernia and gastroschisis, to identify biomarkers that predict prognosis and molecular pathways that may be targets for prenatal intervention.

  • $12.1 million from California Institute for Regenerative Medicine (CIRM) to treat babies in the womb who have alpha thalassemia major. This is a blood disorder that is only detected in the last few months of pregnancy and is almost always fatal. Dr. MacKenzie is using hematopoietic stem cells (HSCs), taken from the mother's bone marrow, and transplanting them into the baby before birth. The baby's immune system is able to tolerate the mother's cells, increasing the chances of a healthy birth, and improving the chances of having effective treatments after birth.
  • T cell activation and the breakdown of maternal-fetal tolerance in preterm labor, NIH/NIAID, R01AI116880, Jun 15, 2015 - May 31, 2020, Role: Principal Investigator
ResidentYearsGrant or Funding Source
Cerine Jeanty, M.D. 2011-
Eveline Shue, M.D. 2011-2013
Amar Nijagal, M.D. 2009-2012 CA Institute for Regenerative Medicine Clinical Fellow Training Award
Most recent publications from a total of 57
  1. Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ. Large Differences in Small RNA Composition Between Human Biofluids. Cell Rep. 2018 Oct 30; 25(5):1346-1358. View in PubMed
  2. Witt RG, Zobel M, Padilla B, Lee H, MacKenzie TC, Vu L. Evaluation of Clinical Outcomes of Sutureless vs Sutured Closure Techniques in Gastroschisis Repair. JAMA Surg. 2018 Sep 19. View in PubMed
  3. MacKenzie TC. Future AAVenues for In Utero Gene Therapy. Cell Stem Cell. 2018 Sep 06; 23(3):320-321. View in PubMed
  4. Vora B, Wang A, Kosti I, Huang H, Paranjpe I, Woodruff TJ, MacKenzie T, Sirota M. Meta-Analysis of Maternal and Fetal Transcriptomic Data Elucidates the Role of Adaptive and Innate Immunity in Preterm Birth. Front Immunol. 2018; 9:993. View in PubMed
  5. Frascoli M, Coniglio L, Witt R, Jeanty C, Fleck-Derderian S, Myers DE, Lee TH, Keating S, Busch MP, Norris PJ, Tang Q, Cruz G, Barcellos LF, Gomez-Lopez N, Romero R, MacKenzie TC. Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-? and TNF-a. Sci Transl Med. 2018 Apr 25; 10(438). View in PubMed
  6. Witt RG, Kreger EM, Buckman LB, Moradi PW, Ho PT, Derderian SC, Tsai P, Baker C, Schramm N, Cleary R, Garcia JV, MacKenzie TC. Systemic multilineage engraftment in mice after in utero transplantation with human hematopoietic stem cells. Blood Adv. 2018 Jan 09; 2(1):69-74. View in PubMed
  7. Chumfong I, Lee H, Padilla BE, MacKenzie TC, Vu LT. Esophagoesophagopexy technique for assisted fistulization of esophageal atresia. Pediatr Surg Int. 2018 Jan; 34(1):63-69. View in PubMed
  8. Berger VK, Sparks TN, Jelin AC, Derderian C, Jeanty C, Gosnell K, Mackenzie T, Gonzalez JM. Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? J Ultrasound Med. 2018 May; 37(5):1185-1191. View in PubMed
  9. Padilla BE, Vu L, Lee H, MacKenzie T, Bratton B, O'Day M, Derderian S. Sacrococcygeal teratoma: late recurrence warrants long-term surveillance. Pediatr Surg Int. 2017 Nov; 33(11):1189-1194. View in PubMed
  10. Witt R, MacKenzie TC, Peranteau WH. Fetal stem cell and gene therapy. Semin Fetal Neonatal Med. 2017 Dec; 22(6):410-414. View in PubMed
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