Tippi MacKenzie, M.D.
Assistant Professor of Surgery
Contact Information
University of California, San Francisco
513 Parnassus Avenue
San Francisco, CA 94143-0570
415-476-2538 Office
415-476-2929 Fax
pedsurg@surgery.ucsf.edu
Education
- 1987-91, Harvard University, B.A., Biochemistry
- 1992-97, Stanford University School of Medicine, M.D., Medicine
Residencies
- 1998-99, Brigham and Women's Hospital, Resident, Surgery
- 2002-04, Brigham and Women's Hospital, Resident, Surgery
- 2004-05, Brigham and Women's Hospital, Chief Resident, Surgery
Fellowships
- 1999-02, Children's Hospital of Philadelphia, Fellow, Fetal Therapy
- 2005-07, Children's Hospital of Philadelphia, Fellow, Pediatric Surgery
Board Certification
- American Board of Surgery, 2006
Program Affiliations
- Fetal Treatment Center
- Biomedical Sciences Program
- Institute for Regeneration Medicine
Clinical Expertise
- Pediatric Surgery
- Fetal Surgery
- Birth Defects
- Advanced Laparoscopy
- Endocrine and Biliary Surgery
Research Interests
- In-Utero Stem Cell Transplantation
Biography
Dr. Tippi MacKenzie is an Assistant Professor of Surgery at the UCSF Division of Pediatric Surgery and the Fetal Treatment Center. Dr. MacKenzie obtained her undergraduate degree in Biochemistry at Harvard, then came to the Bay Area for medical school at Stanford. She did her surgical residency at Brigham and Women's Hospital in Boston. During this time, she took three years to do research on fetal surgery and in utero stem cell transplantation at the Children's Hospital of Philadelphia. Following residency, she returned to CHOP for her clinical pediatric surgery fellowship.
Dr. MacKenzie's clinical interests include fetal surgery, advanced laparoscopy, and endocrine and biliary surgery. She has an active laboratory and is a member of the Biomedical Sciences Program and the Institute for Regeneration Medicine. Her research focus is on mechanisms of tolerance induction following in utero stem cell transplantation.
Selected Publications
- Sabatino DE, Mackenzie TC, Peranteau W, Edmonson S, Campagnoli
C, Liu YL,
Flake AW, High KA.
Persistent expression of hF.IX After tolerance induction by in utero or neonatal
administration of AAV-1-F.IX in hemophilia B mice.
Mol Ther. 2007 Sep;15(9):1677-85. Epub 2007 Jun 12. - Keswani SG, Crombleholme TM, Rychik J, Tian Z, Mackenzie TC,
Johnson MP,
Wilson RD, Flake AW, Hedrick HL, Howell LJ, Adzick NS.
Impact of continuous intraoperative monitoring on outcomes in open fetal surgery.
Fetal Diagn Ther. 2005 Jul-Aug;20(4):316-20. - MacKenzie TC, Kobinger GP, Louboutin JP, Radu A, Javazon EH,
Sena-Esteves M,
Wilson JM, Flake AW.
Transduction of satellite cells after prenatal intramuscular administration of
lentiviral vectors.
J Gene Med. 2005 Jan;7(1):50-8. - Bouchard S, MacKenzie TC, Radu AP, Hayashi S, Peranteau WH,
Chirmule N, Flake
AW.
Long-term transgene expression in cardiac and skeletal muscle following fetal
administration of adenoviral or adeno-associated viral vectors in mice.
J Gene Med. 2003 Nov;5(11):941-50. - MacKenzie TC, Kobinger GP, Kootstra NA, Radu A, Sena-Esteves M,
Bouchard S,
Wilson JM, Verma IM, Flake AW.
Efficient transduction of liver and muscle after in utero injection of lentiviral
vectors with different pseudotypes.
Mol Ther. 2002 Sep;6(3):349-58.
In the News
Brilliance and Precision: From Surgery to In Utero Transplantation
UCSF News - Jun 15, 2009As a gifted pianist in high school, Assistant Professor of Surgery Tippi MacKenzie, MD, spent every Saturday studying music at Juilliard. This musical training was good preparation for her current work as a researcher and surgeon.
