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Message from the Chief
Hanmin Lee,
M.D.
Associate Professor & Chief, Division of Pediatric
Surgery
Director, Fetal Treatment Center
Dr. Michael Harrison Endowment Fund
Make a gift to the Endowed Chair in Fetal Treatment . This chair supports innovative research and the training of future fetal interventionalists.
Make a Gift
A gift to Pediatric Surgery helps provide surgical care for fetuses, infants, children, and adolescents.
In Memoriam
Dr. Alfred de Lorimier, a pioneer in pediatric surgery and the founder of the Division of Pediatric Surgery at UCSF, has passed away.
Tippi MacKenzie, M.D.
Assistant Professor of Surgery
Division of Pediatric Surgery
Contact Information
University of California, San Francisco
513 Parnassus Avenue
San Francisco, CA 94143-0570
415-476-2538 Office
415-476-2929 Fax
pedsurg@surgery.ucsf.edu
BiographyEducation
- 1987-91, Harvard University, B.A., Biochemistry
- 1992-97, Stanford University School of Medicine, M.D., Medicine
Residencies
- 1998-99, Brigham and Women's Hospital, Resident, Surgery
- 2002-04, Brigham and Women's Hospital, Resident, Surgery
- 2004-05, Brigham and Women's Hospital, Chief Resident, Surgery
Fellowships
- 1999-02, Children's Hospital of Philadelphia, Fellow, Fetal Therapy
- 2005-07, Children's Hospital of Philadelphia, Fellow, Pediatric Surgery
Board Certification
- American Board of Surgery, 2006
Program Affiliations
- Biomedical Sciences Program
- Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
- Fetal Treatment Center
Clinical Expertise
- Advanced Laparoscopy
- Birth Defects
- Endocrine and Biliary Surgery
- Fetal Surgery
- Pediatric Surgery
Research Interests
- In-Utero Stem Cell Transplantation
Biography
Dr. Tippi MacKenzie is an Assistant Professor of Surgery at the UCSF Division of Pediatric Surgery and the Fetal Treatment Center. Dr. MacKenzie obtained her undergraduate degree in Biochemistry at Harvard, then came to the Bay Area for medical school at Stanford. She did her surgical residency at Brigham and Women's Hospital in Boston. During this time, she took three years to do research on fetal surgery and in utero stem cell transplantation at the Children's Hospital of Philadelphia. Following residency, she returned to CHOP for her clinical pediatric surgery fellowship.
Dr. MacKenzie's clinical interests include fetal surgery, advanced laparoscopy, and endocrine and biliary surgery.
Research Summary
Dr Tippi MacKenzie has an active laboratory and is a member of the Biomedical Sciences Program and the Institute for Regeneration Medicine. Her research focus is on mechanisms of tolerance induction following in utero stem cell transplantation.
Selected Publications
- Sabatino DE, Mackenzie TC, Peranteau W, Edmonson S, Campagnoli
C, Liu YL,
Flake AW, High KA.
Persistent expression of hF.IX After tolerance induction by in utero or neonatal
administration of AAV-1-F.IX in hemophilia B mice.
Mol Ther. 2007 Sep;15(9):1677-85. Epub 2007 Jun 12. - Keswani SG, Crombleholme TM, Rychik J, Tian Z, Mackenzie TC,
Johnson MP,
Wilson RD, Flake AW, Hedrick HL, Howell LJ, Adzick NS.
Impact of continuous intraoperative monitoring on outcomes in open fetal surgery.
Fetal Diagn Ther. 2005 Jul-Aug;20(4):316-20. - MacKenzie TC, Kobinger GP, Louboutin JP, Radu A, Javazon EH,
Sena-Esteves M,
Wilson JM, Flake AW.
Transduction of satellite cells after prenatal intramuscular administration of
lentiviral vectors.
J Gene Med. 2005 Jan;7(1):50-8. - Bouchard S, MacKenzie TC, Radu AP, Hayashi S, Peranteau WH,
Chirmule N, Flake
AW.
Long-term transgene expression in cardiac and skeletal muscle following fetal
administration of adenoviral or adeno-associated viral vectors in mice.
J Gene Med. 2003 Nov;5(11):941-50. - MacKenzie TC, Kobinger GP, Kootstra NA, Radu A, Sena-Esteves M,
Bouchard S,
Wilson JM, Verma IM, Flake AW.
Efficient transduction of liver and muscle after in utero injection of lentiviral
vectors with different pseudotypes.
Mol Ther. 2002 Sep;6(3):349-58.
In the News
Treating Disease Before Birth with Tippi MacKenzie, MD
UCSF - Jul 05, 2011Stem cell transplantation may hold the promise to treating many diseases before birth such as sickle cell anemia and muscular dystrophy. But first, researchers need to overcome many barriers, including rejection of stem cell transplants by the fetus. MacKenzie's lab recently discovered that mothers' T cells are responsible for rejecting the grafts and that this rejection may be avoided by using stem cells from the mother.
Spina Bifida Study a "Huge Gamechanger for Fetal Surgery"
New York Times - Feb 09, 2011For years, surgeons have been seeking ways of operating on babies in the womb, reasoning that medical abnormalities are easier to address while the fetus is still developing. Now, for the first time, a large clinical trial has shown that fetal surgery can also benefit infants with non life-threatening conditions. The eight-year study, led by Dr. Diana Farmer, Chief of the Division of Pediatric Surgery at UCSF, reported in the New England Journal of Medicine, found that babies born with myelomeningocele, the most common form of spina bifida, a debilitating spinal abnormality, were twice as likely to walk and experienced fewer neurological problems with in utero repair versus standard post-natal repair. Dr. Farmer characterized it as a " huge game-changer for fetal surgery". Dr. Michael Harrison, who pioneered fetal surgery at UCSF, was a principal investigator on the trial before retiring.
Mother’s stem cells likely key to treating genetic disease before birth
UCSF News - Jan 18, 2011UCSF researchers have tackled a decade-long scientific conundrum, and their discovery is expected to lead to significant advances in using stem cells to treat genetic diseases before birth. Through a series of mouse model experiments, the research team determined that a mother's immune response prevents a fetus from accepting transplanted blood stem cells, and yet this response can be overcome simply by transplanting cells harvested from the mother herself.
Institute for Fetal and Neonatal Health 1st Annual Research Symposium
UCSF Pediatric Surgery - Nov 02, 2010UCSF announces the formation of the Institute for Fetal and Neonatal Health symposium brings together clinicians and basic scientists involved in different aspects of development and fetal intervention.
Brilliance and Precision: From Surgery to In Utero Transplantation
UCSF News - Jun 15, 2009As a gifted pianist in high school, Assistant Professor of Surgery Tippi MacKenzie, MD, spent every Saturday studying music at Julliard. This musical training was good preparation for her current work as a researcher and surgeon.
Read the full article [pdf 185KB]
